methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

Base Information

Chemical Name:methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate
CAS No.:1598383-56-2
Molecular Formula:C₂₁H₃₃BrN₂O₃
Molecular Weight:441.409
Hs Code.:

Synonyms:methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

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Chemical Property of methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

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Technology Process of methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

There total 6 articles about methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

: 1598383-55-1
methyl 5-bromo-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methylbenzoate

: 6482-24-2
2-Bromoethyl methyl ether

: 1598383-56-2
methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 65 ℃; for 16h;
DOI:10.1021/acsmedchemlett.5b00037

Reference yield:

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1598383-56-2
methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C

3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C

With hydrogenchloride; sodium hydride; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1598383-48-2
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)(methyl)amino)cyclohexyl)(ethyl)amino)-2-methylbenzoate

: 1598383-56-2
methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 2 h / 0 - 20 °C

2: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In methanol; acetonitrile;