2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

Base Information

Chemical Name:2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl
CAS No.:1354758-59-0
Molecular Formula:C₂₄H₂₁ClFN₅
Molecular Weight:433.916
Hs Code.:

Synonyms:2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

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Chemical Property of 2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

Chemical Property:

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Technology Process of 2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

There total 10 articles about 2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl dihydrochloride

: 1354758-59-0
2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

Guidance literature:: With sodium hydroxide; In water; pH=14;

Reference yield:

: 1354758-78-3
2-(5-chloro-2-fluoro-phenyl)-4-iodo-pyridine

: 1354758-59-0
2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2: hydrogenchloride; water / 5 h / 20 °C

3: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 18 h / 80 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

5: sodium hydroxide / water / pH 14

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; potassium acetate; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2-(5-chloro-2-fluoro-phenyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

: 1354758-59-0
2'-(5-chloro-2-fluoro-phenyl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / 5 h / 20 °C

2: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 18 h / 80 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

4: sodium hydroxide / water / pH 14

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;