Technology Process of tert-butyl (2S,3S)-3-[benzyl-[(1S)-1-phenylethyl]amino]-2-hydroxy-heptanoate
There total 4 articles about tert-butyl (2S,3S)-3-[benzyl-[(1S)-1-phenylethyl]amino]-2-hydroxy-heptanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C26H36NO2(1-)*Li(1+);
With
(1S)-(+)-(10-camphorsulfonyl)-oxaziridine;
In
tetrahydrofuran; n-heptane;
at -65 - -55 ℃;
for 6h;
Industry scale;
With
acetic acid;
In
tetrahydrofuran; n-heptane;
at -60 - -40 ℃;
Industry scale;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / 60 h / 5 - 35 °C / Industry scale
1.2: 30 °C / Industry scale
2.1: sulfuric acid / n-heptane / 18 h / 19 - 25 °C / Industry scale; Sealed vessel
3.1: n-hexyllithium / n-heptane; tetrahydrofuran / 0.5 h / -65 - -55 °C / Industry scale
3.2: 1.5 h / -65 - -55 °C / Industry scale
4.1: (1S)-(+)-(10-camphorsulfonyl)-oxaziridine / n-heptane; tetrahydrofuran / 6 h / -65 - -55 °C / Industry scale
4.2: -60 - -40 °C / Industry scale
With
pyridine; n-hexyllithium; (1S)-(+)-(10-camphorsulfonyl)-oxaziridine;
sulfuric acid;
In
tetrahydrofuran; n-heptane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / n-heptane / 18 h / 19 - 25 °C / Industry scale; Sealed vessel
2.1: n-hexyllithium / n-heptane; tetrahydrofuran / 0.5 h / -65 - -55 °C / Industry scale
2.2: 1.5 h / -65 - -55 °C / Industry scale
3.1: (1S)-(+)-(10-camphorsulfonyl)-oxaziridine / n-heptane; tetrahydrofuran / 6 h / -65 - -55 °C / Industry scale
3.2: -60 - -40 °C / Industry scale
With
n-hexyllithium; (1S)-(+)-(10-camphorsulfonyl)-oxaziridine;
sulfuric acid;
In
tetrahydrofuran; n-heptane;
