5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Base Information

Chemical Name:5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide
CAS No.:1417797-77-3
Molecular Formula:C₂₂H₂₃NO₄S₂
Molecular Weight:429.561
Hs Code.:

Synonyms:5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

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Chemical Property of 5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

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Technology Process of 5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

There total 8 articles about 5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1417798-24-3
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,3,4-trimethylthiophene-2-carboxamide

: 925-90-6
ethylmagnesium bromide

: 1417797-77-3
5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,3,4-trimethylthiophene-2-carboxamide; ethylmagnesium bromide; In tetrahydrofuran; at 25 - 75 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 1417798-16-3
methyl 5-(4-methoxyphenyl)-3,4-dimethylthiophene-2-carboxylate

: 1417797-77-3
5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; bromine / 3 h / 25 °C

2.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

2.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

3.1: sodium hydroxide; water / ethanol / 1.5 h / 0 - 80 °C

3.2: pH 6 - 7

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: tetrahydrofuran / 1 h / 25 - 75 °C

5.2: 0 °C

With oxalyl dichloride; water; bromine; potassium carbonate; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1417798-18-5
methyl 5-(3-bromo-4-methoxyphenyl)-3,4-dimethylthiophene-2-carboxylate

: 1417797-77-3
5'-(3,4-dimethyl-5-propionylthiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

1.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

2.1: sodium hydroxide; water / ethanol / 1.5 h / 0 - 80 °C

2.2: pH 6 - 7

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: tetrahydrofuran / 1 h / 25 - 75 °C

4.2: 0 °C

With oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene;