ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

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Chemical Name:ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate
CAS No.:1334608-07-9
Molecular Formula:C₃₁H₃₈ClN₃O₃
Molecular Weight:536.114
Hs Code.:

Synonyms:ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

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Chemical Property of ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

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Technology Process of ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

There total 11 articles about ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334608-06-8
2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-[2-ethyl-3-(4-piperidinyl)phenyl]pyrimidine

: 140-88-5,9003-32-1
ethyl acrylate

: 1334608-07-9
ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 3h; Inert atmosphere; Sealed;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1334608-07-9
ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2: hydrogenchloride; acetic acid / water / 12 h / Reflux

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 50 °C / 2844.39 Torr

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / 80 °C / Inert atmosphere; Sealed

With hydrogenchloride; n-butyllithium; hydrogen; potassium acetate; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; water; ethyl acetate; acetonitrile;

Reference yield:

: 201849-21-0
4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

: 1334608-07-9
ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / 80 °C / Inert atmosphere; Sealed

With potassium acetate; sodium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;