2-(Thiophen-3-yl)acetohydrazide

Base Information

• Chemical Name: 2-(Thiophen-3-yl)acetohydrazide
• CAS No.: 175276-94-5
• Molecular Formula: C6H8 N2 O S
• Molecular Weight: 156.208
• Hs Code.: 2934999090
• European Community (EC) Number: 681-393-1
• DSSTox Substance ID: DTXSID60332839
• Nikkaji Number: J1.451.069I
• Wikidata: Q82097699
• ChEMBL ID: CHEMBL3091846
• Mol file: 175276-94-5.mol

Synonyms:175276-94-5;2-(thiophen-3-yl)acetohydrazide;Thiophene-3-acetic acid hydrazide;2-thiophen-3-ylacetohydrazide;2-(Thien-3-yl)acetohydrazide;3-Thiopheneacetic acid, hydrazide;2-(3-Thienyl)acetohydrazide;thiophene-3-acetic hydrazide;3-Thiopheneacetic acid,hydrazide;Maybridge1_008350;(3-Thienyl)acetohydrazide;Oprea1_029901;2-thiophen-3-ylethanehydrazide;2-(3-thiophenyl)acetohydrazide;SCHEMBL1129020;2-(3-Thienyl)acetohydrazide #;CHEMBL3091846;HMS565D12;DTXSID60332839;3-Thiophenylacetic acid, hydrazide;2-(3-Thienyl)acetic acid hydrazide;MFCD00052946;AKOS008968523;SB86512;AS-61580;CS-0448653;FT-0643693;EN300-77510;Thiophene-3-acetic acid hydrazide, AldrichCPR;A811988;J-011091

Chemical Property of 2-(Thiophen-3-yl)acetohydrazide

Chemical Property:

• Vapor Pressure: 3.29E-06mmHg at 25°C
• Melting Point: 85-86°C
• Boiling Point: 387.5°Cat760mmHg
• Flash Point: 188.1°C
• PSA: 83.36000
• Density: 1.287g/cm³
• LogP: 1.37170
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 156.03573406
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

Thiophene-3-aceticAcidHydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC=C1CC(=O)NN

Technology Process of 2-(Thiophen-3-yl)acetohydrazide

There total 1 articles about 2-(Thiophen-3-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-3 thiophene acetate (37784-63-7) → 2-(thiophen-3-yl)acetohydrazide (175276-94-5)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01104a046

Reference yield: 62.0%

2-(thiophen-3-yl)acetohydrazide (175276-94-5) + 2-(phenylsulfonyl)acetonitrile (7605-28-9) → 3-benzenesulfonylmethyl-5-thiophen-3-ylmethyl-1H-[1,2,4]triazole

Guidance literature:

With potassium carbonate; In butan-1-ol; at 150 ℃; for 1h; microwave irradiation;

DOI:10.1016/j.tetlet.2005.02.167

Reference yield: 59.0%

2-(thiophen-3-yl)acetohydrazide (175276-94-5) + (4-carbamimidoylphenylamino)-(3-ethoxy-4-isopropoxyphenyl)acetic acid hydrochloride + trifluoroacetic acid (76-05-1) → 4-(1-(3-ethoxy-4-isopropoxyphenyl)-2-oxo-2-(N'-(2-thiophen-3-ylacetyl)hydrazino)ethylamino)benzamidine trifluoroacetate

Guidance literature:

(4-carbamimidoylphenylamino)-(3-ethoxy-4-isopropoxyphenyl)acetic acid hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; at 0 ℃; for 1h;

2-(thiophen-3-yl)acetohydrazide; In water; N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

upstream raw materials:

ethyl-3 thiophene acetate