Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

Base Information

Chemical Name:Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>
CAS No.:120286-05-7
Molecular Formula:C₅₄H₈₅N₇O₁₃
Molecular Weight:1040.31
Hs Code.:

Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<<N-<(2S,3S,4S)-4-<<(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl>oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

Synonyms:Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

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Chemical Property of Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

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Technology Process of Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

There total 26 articles about Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 161708-52-7
C₆₂H₈₉N₇O₁₅

: 120286-05-7
Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 12h; under 2068.6 Torr;
DOI:10.1021/jo00097a022

Reference yield:

: 120286-10-4
N-(Z-L-Pro)didemnin A

: 120286-05-7
Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

Guidance literature:: With hydrogen; Yield given;
DOI:10.1016/S0040-4039(00)80507-9

Reference yield:

: 77327-04-9
Didemnin A

: 120286-05-7
Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DCC / 1.) CH₂Cl₂, 5 deg C, 2 h, 2.) CH₂Cl₂, 10 deg C, 8 h

2: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;
DOI:10.1021/jm960048g