N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide

Base Information

• Chemical Name: N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide
• CAS No.: 1253787-37-9
• Molecular Formula: C₂₁H₂₂F₃IN₂O₅S
• Molecular Weight: 598.382

Synonyms:N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide

Chemical Property of N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide

Chemical Property:

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Technology Process of N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide

There total 4 articles about N₂-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N2-[1,1-dimethyl-2-(methylthio)ethyl]-3-iodo-N1-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide (1253787-11-9) → N2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N1-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide (1253787-37-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jf1021708

Reference yield:

3-iodophthalic anhydride (28418-88-4) → N2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N1-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide (1253787-37-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 5 °C

2.2: 10 °C

3.1: dichloromethane / Cooling with ice

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jf1021708

Reference yield:

3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-o-carbamoylbenzoic acid (866639-19-2) → N2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N1-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide (1253787-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 5 °C

1.2: 10 °C

2.1: dichloromethane / Cooling with ice

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jf1021708

upstream raw materials:

N₂-[1,1-dimethyl-2-(methylthio)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide

3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-o-carbamoylbenzoic acid

3-iodophthalic anhydride

2-methyl-1-methylthio-2-propylamine

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