2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid

Base Information

• Chemical Name: 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid
• CAS No.: 221535-99-5
• Molecular Formula: C₃₂H₃₅N₃O₅
• Molecular Weight: 541.647

Synonyms:2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid

Chemical Property of 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid

Chemical Property:

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Technology Process of 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid

There total 1 articles about 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetate (221534-74-3) → 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid (221535-99-5)

Guidance literature:

Reference yield: 83.0%

2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid (221535-99-5) + sarcosine ethyl ester hydrochloride (52605-49-9) → 2,4-Dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-N-ethoxycarbonylmethyl-N-methyl-1,2,3,4-tetrahydroquinazoline-3-acetamide hydrochloride (221538-27-8)

Guidance literature:

Reference yield: 80.0%

ethyl ether-ethyl acetate + 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid (221535-99-5) + hydrochloride of 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid + bromoacetic acid methyl ester (96-32-2) → methoxycarbonylmethyl 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetate hydrochloride (221536-43-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetate

Downstream raw materials:

N-(1-Ethoxycarbonyl-1-methyl)ethyl-2-[2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazolin-3-yl]acetamide

2,4-Dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-N-methoxycarbonylmethyl-1,2,3,4-tetrahydroquinazoline-3-acetamide hydrochloride

2,4-Dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-N-(2-ethoxycarbonylethyl)-1,2,3,4-tetrahydroquinazoline-3-acetamide hydrochloride

methoxycarbonylmethyl 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetate hydrochloride

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