2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

Base Information

Chemical Name:2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile
CAS No.:1258855-52-5
Molecular Formula:C₂₂H₂₃N₅O
Molecular Weight:373.458
Hs Code.:

Synonyms:2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

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Chemical Property of 2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

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Technology Process of 2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

There total 7 articles about 2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258855-53-6
1,1-dimethylethyl 7-{5-[3-cyano-4-(propylamino)phenyl]-1,2,4-oxadiazol-3-yl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-52-5
2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-52-5
2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 2 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 171050-06-9
3-cyano-4-fluorobenzoic acid

: 1258855-52-5
2-(propylamino)-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 0.25 h

2: pyridine / toluene / 2 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;