C₄₂H₆₀O₈Si

Base Information

Chemical Name:C₄₂H₆₀O₈Si
CAS No.:880344-61-6
Molecular Formula:C₄₂H₆₀O₈Si
Molecular Weight:721.019
Hs Code.:

C<sub>42</sub>H<sub>60</sub>O<sub>8</sub>Si

Synonyms:C₄₂H₆₀O₈Si

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Chemical Property of C₄₂H₆₀O₈Si

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Technology Process of C₄₂H₆₀O₈Si

There total 25 articles about C₄₂H₆₀O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 880344-60-5
C₄₈H₇₄O₈Si₂

: 880344-61-6
C₄₂H₆₀O₈Si

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1021/ja0547477

Reference yield:

: 157240-43-2
(4R)-4,5-isopropylidenedioxy-1-(dimethoxyphosphoryl)-2-pentanone

: 880344-61-6
C₄₂H₆₀O₈Si

Guidance literature:: Multi-step reaction with 26 steps

1.1: LiCl; N,N-diisopropylethylamine / acetonitrile / 2 h / 25 °C

1.2: 86 percent / acetonitrile / 15 h / 25 °C

2.1: 98 percent / LiI; LiAlH₄ / diethyl ether / -100 - 0 °C

3.1: 97 percent / AcOH / H₂O / 5 h / 40 °C

4.1: 70 percent / NaHCO₃; N-iodosuccinimide / tetrahydrofuran / 36 h / 0 °C

5.1: 99 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 10 h / 25 °C

6.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

7.1: 99 percent / H₂; Raney-Ni catalyst / ethanol / 1 h / 25 °C

8.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

9.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

10.1: Mg / tetrahydrofuran / 2 h / 25 °C

10.2: tetrahydrofuran / 2 h / -78 - 0 °C

11.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

12.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

13.1: N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 14 h / 25 °C

13.2: 100 percent / NaIO₄; aq. saline solution buffer / tetrahydrofuran; 2-methyl-propan-2-ol / 5 h / 25 °C

14.1: n-BuLi / tetrahydrofuran; toluene / 3 h / -30 °C

14.2: tetrahydrofuran / 1 h / -30 °C

15.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

16.1: 85 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

17.1: 95 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 25 °C

18.1: 91 percent / 2,6-lutidine; N-bromosuccinimide / acetonitrile; H₂O / 2 h / 25 °C

19.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

20.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

21.1: 92 percent / imidazole; 4-DMAP / CH₂Cl₂ / 10 h / -78 - 0 °C

22.1: 87 percent / diisobutylaluminum hydride / CH₂Cl₂ / 1 h / -78 °C

23.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

24.1: n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C

24.2: 45 mg / tetrahydrofuran / 0.5 h / -78 - 0 °C

25.1: 65 percent / Grubbs second generation catalyst / CH₂Cl₂ / 12 h / 40 °C

26.1: 94 percent / pyridine; HF / tetrahydrofuran / 5 h / 0 °C

With pyridine; 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; N-Bromosuccinimide; N-iodo-succinimide; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; Raney-Ni catalyst; hydrogen fluoride; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; acetic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; trifluoroacetic acid; lithium chloride; lithium iodide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; 23.1: Swern oxidation;
DOI:10.1021/ja0547477

Reference yield:

: 392663-07-9
(2R,3S,5R)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

: 880344-61-6
C₄₂H₆₀O₈Si

Guidance literature:: Multi-step reaction with 20 steps

1.1: 99 percent / H₂; Raney-Ni catalyst / ethanol / 1 h / 25 °C

2.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

3.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

4.1: Mg / tetrahydrofuran / 2 h / 25 °C

4.2: tetrahydrofuran / 2 h / -78 - 0 °C

5.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

6.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

7.1: N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 14 h / 25 °C

7.2: 100 percent / NaIO₄; aq. saline solution buffer / tetrahydrofuran; 2-methyl-propan-2-ol / 5 h / 25 °C

8.1: n-BuLi / tetrahydrofuran; toluene / 3 h / -30 °C

8.2: tetrahydrofuran / 1 h / -30 °C

9.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

10.1: 85 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

11.1: 95 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 25 °C

12.1: 91 percent / 2,6-lutidine; N-bromosuccinimide / acetonitrile; H₂O / 2 h / 25 °C

13.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

14.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

15.1: 92 percent / imidazole; 4-DMAP / CH₂Cl₂ / 10 h / -78 - 0 °C

16.1: 87 percent / diisobutylaluminum hydride / CH₂Cl₂ / 1 h / -78 °C

17.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

18.1: n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C

18.2: 45 mg / tetrahydrofuran / 0.5 h / -78 - 0 °C

19.1: 65 percent / Grubbs second generation catalyst / CH₂Cl₂ / 12 h / 40 °C

20.1: 94 percent / pyridine; HF / tetrahydrofuran / 5 h / 0 °C

With pyridine; 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; N-Bromosuccinimide; osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; Raney-Ni catalyst; hydrogen fluoride; hydrogen; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; orthoformic acid triethyl ester; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; 17.1: Swern oxidation;
DOI:10.1021/ja0547477