(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

Base Information

Chemical Name:(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate
CAS No.:1315337-22-4
Molecular Formula:C₂₇H₂₂F₄NO₃P
Molecular Weight:515.444
Hs Code.:

Synonyms:(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

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Chemical Property of (E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

Chemical Property:

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Technology Process of (E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

There total 4 articles about (E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1315337-21-3
4-phenyl-2-(2,3,5,6-tetrafluorophenyl)quinoline

: 682-30-4
Diethyl vinylphosphonate

: 1315337-22-4
(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

Guidance literature:: With palladium diacetate; silver carbonate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 120 ℃; for 16h; sealed tube;
DOI:10.1021/ol201706t

Reference yield:

: 1174281-24-3
quinoline-2,4-diyl bis(4-methylbenzenesulfonate)

: 1315337-22-4
(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; CyJohnPhos / tert-butyl alcohol / 12 h / 90 °C / Inert atmosphere; sealed tube

2: potassium phosphate; palladium diacetate; XPhos / tetrahydrofuran / 6 h / 80 °C / sealed tube; Inert atmosphere

3: palladium diacetate; silver carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 16 h / 120 °C / sealed tube

With potassium phosphate; palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; palladium diacetate; silver carbonate; CyJohnPhos; XPhos; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol201706t

Reference yield:

: 1315337-20-2
2-(2,3,5,6-tetrafluorophenyl)quinolin-4-yl-4-methylbenzenesulfonate

: 1315337-22-4
(E)-diethyl 2,3,5,6-tetrafluoro-4-(4-phenylquinolin-2-yl)styrylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; XPhos / tetrahydrofuran / 6 h / 80 °C / sealed tube; Inert atmosphere

2: palladium diacetate; silver carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 16 h / 120 °C / sealed tube

With potassium phosphate; palladium diacetate; silver carbonate; XPhos; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol201706t