(2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate
• CAS No.: 1250939-15-1
• Molecular Formula: C₁₉H₂₄BrN₃O₂
• Molecular Weight: 406.322

Synonyms:(2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate

Chemical Property of (2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

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Technology Process of (2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate

There total 20 articles about (2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (1250939-12-8) → (2S,5S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate (1250939-15-1)

Guidance literature:

With ammonium acetate; In toluene; at 120 ℃; for 5h;

Reference yield: 81.0%

(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (1250939-12-8) → (2S,5S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1250939-15-1)

Guidance literature:

With ammonium acetate; In xylene; at 140 ℃; for 5h; Sealed vessel;

Reference yield:

C19H25BrN2O4 (1359869-70-7) → (2S,5S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1250939-15-1)

Guidance literature:

C₁₉H₂₅BrN₂O₄; With ammonium acetate; In xylene; at 130 ℃; for 12h; Sealed tube;

With sodium hydrogencarbonate;

upstream raw materials:

(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

(S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester

Downstream raw materials:

C₂₅H₃₆BN₃O₄

C₃₈H₄₇FN₆O₄

C₂₅H₃₆BN₃O₄

4-(4-bromo-phenyl)-2-((2S,5S)-5-methyl-pyrrolidin-2-yl)-1H-imidazole

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