trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

Base Information

Chemical Name:trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene
CAS No.:120883-59-2
Molecular Formula:C₂₇H₄₇NOSi
Molecular Weight:429.762
Hs Code.:

Synonyms:trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

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Chemical Property of trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

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Technology Process of trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

There total 14 articles about trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 120883-58-1
Toluene-4-sulfonic acid 4-[(5R,6R)-6-butyl-5-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl]-butyl ester

: 100-46-9
benzylamine

: 120883-59-2
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

Guidance literature:: With sodium iodide; In dimethyl sulfoxide; for 12h; Ambient temperature;
DOI:10.1021/jo00275a023

Reference yield:

: 120883-61-6
trans-2-butyl-3-hydroxy-1-cyclohexanone

: 120883-59-2
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) 12 h

3: 1.) copper(I) iodide / 1.) THF, -78 deg C, 30 min, 2.) -20 deg C, 12 h

4: 98 percent / ammonia, sodium / diethyl ether / 1 h / -78 °C

5: 98 percent / pyridine / -20 - 0 °C

6: 87 percent / NaI / dimethylsulfoxide / 12 h / Ambient temperature

With pyridine; 1H-imidazole; copper(l) iodide; ammonia; sodium; sodium iodide; lithium diisopropyl amide; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a023

Reference yield:

: 120883-52-5
(4-Cyclohexa-1,5-dienyl-butoxymethyl)-benzene

: 120883-59-2
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(N-(phenylmethyl)amino)butyl)cyclohexene

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / LiCl, LiOAc*2H₂O, Pd(OAc)2, p-benzoquinone / acetone / 8 h

2: 89 percent / CuCN / diethyl ether / 4 h / 0 °C

3: 98 percent / 5percent aq. MeOH, K₂CO₃ / 24 h / Ambient temperature

4: 92 percent / imidazole / dimethylformamide / 3 h / 0 - 20 °C

5: 98 percent / ammonia, sodium / diethyl ether / 1 h / -78 °C

6: 98 percent / pyridine / -20 - 0 °C

7: 87 percent / NaI / dimethylsulfoxide / 12 h / Ambient temperature

With pyridine; 1H-imidazole; methanol; palladium diacetate; lithium acetate; ammonia; sodium; potassium carbonate; p-benzoquinone; sodium iodide; lithium chloride; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00275a023