(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

Base Information

Chemical Name:(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol
CAS No.:272124-14-8
Molecular Formula:C₂₈H₂₉N₃O₄
Molecular Weight:471.556
Hs Code.:

Synonyms:(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

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Chemical Property of (5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

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Technology Process of (5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

There total 5 articles about (5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 272124-13-7
(5R,6R,7S,8S)-8-acetoxy-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[1,2-a]pyridine

: 272124-14-8
(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

Guidance literature:: With ammonia; In tetrahydrofuran; methanol; at 40 ℃; for 0.5h;
DOI:10.1002/(SICI)1522-2675(20000315)83:3<513::AID-HLCA513>3.0.CO;2-1

Reference yield:

: 77174-08-4
(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)piperidin-2-one

: 272124-14-8
(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / Bu₄NBr; BCl₃ / CH₂Cl₂ / 6 h / -78 - 23 °C

2: 98 percent / pyridine / 2 h / 23 °C

3: 92 percent / anisyldithiophosphinic anhydride / toluene / 2 h / 25 °C

4: 89 percent / Hg(OAc)2 / tetrahydrofuran / 3 h / 23 °C

5: 98 percent / NH₃ / tetrahydrofuran; methanol / 0.5 h / 40 °C

With Lawessons reagent; pyridine; mercury(II) diacetate; tetrabutylammomium bromide; ammonia; boron trichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: regioselective debenzylation / 2: Acetylation / 3: Substitution / 4: Condensation / 5: Deacetylation;
DOI:10.1002/(SICI)1522-2675(20000315)83:3<513::AID-HLCA513>3.0.CO;2-1

Reference yield:

: 272123-95-2
5-amino-3,4,6-tri-O-benzyl-5-deoxy-D-gluconolactam

: 272124-14-8
(5R,6R,7R,8S)-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydrotriazolo[4,3-a]pyridin-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / pyridine / 2 h / 23 °C

2: 92 percent / anisyldithiophosphinic anhydride / toluene / 2 h / 25 °C

3: 89 percent / Hg(OAc)2 / tetrahydrofuran / 3 h / 23 °C

4: 98 percent / NH₃ / tetrahydrofuran; methanol / 0.5 h / 40 °C

With Lawessons reagent; pyridine; mercury(II) diacetate; ammonia; In tetrahydrofuran; methanol; toluene; 1: Acetylation / 2: Substitution / 3: Condensation / 4: Deacetylation;
DOI:10.1002/(SICI)1522-2675(20000315)83:3<513::AID-HLCA513>3.0.CO;2-1