Technology Process of 2-hydroxy-4-methyl-6-(2-(naphthalen-2-yl)ethyl)benzoic acid
There total 8 articles about 2-hydroxy-4-methyl-6-(2-(naphthalen-2-yl)ethyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol; ethyl acetate;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmcl.2013.01.074
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; acetic acid; water / 12 h / Reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 50 °C / Inert atmosphere
3.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 2 h / 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; boron tribromide; sodium hydride; acetic acid;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2013.01.074
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: hydrogenchloride; acetic acid; water / 12 h / Reflux
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 50 °C / Inert atmosphere
4.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere
5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 2 h / 20 °C
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; palladium 10% on activated carbon; water; hydrogen; sec.-butyllithium; boron tribromide; sodium hydride; acetic acid;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane; ethyl acetate;
3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2013.01.074
