Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

Base Information

Chemical Name:Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide
CAS No.:1607464-87-8
Molecular Formula:C₃₉H₃₈N₄O₅S
Molecular Weight:674.821
Hs Code.:

Synonyms:Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

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Technology Process of Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

There total 1 articles about Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 71989-38-3,118488-18-9,204384-67-8
Fmoc-Tyr(tBu)-OH

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1607464-87-8
Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 3h; Reflux;
DOI:10.1002/chem.201303664

Reference yield: 86.0%

: 1607464-87-8
Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

: 1607464-89-0
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)tert-butoxytyrosinamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/chem.201303664

Reference yield:

: 1607464-87-8
Nα-fluorenylmethyloxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]tert-butoxytyrosinamide

: 1607464-97-0
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)tyrosinamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/chem.201303664