(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

Base Information

Chemical Name:(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester
CAS No.:854371-64-5
Molecular Formula:C₂₉H₃₀N₂O₅S
Molecular Weight:518.634
Hs Code.:

Synonyms:(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

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Chemical Property of (R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

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Technology Process of (R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

There total 2 articles about (R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 57876-69-4
2-chloro-3-methyl-quinoline

: 854371-63-4
(R)-2-(4'-hydroxymethyl-biphenyl-4-sulfonylamino)-3-methyl-butyric acid methyl ester

: 854371-64-5
(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

Guidance literature:: With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 - 100 ℃;

Reference yield:

: 544709-92-4
methyl N-[(4-bromophenyl)sulfonyl]-D-valinate

: 1160829-14-0
C₂₃H₂₆BNO₃

: 854371-64-5
(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃;
DOI:10.1016/j.bmcl.2009.03.056

Reference yield: 76.3%

: 854371-64-5
(R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester

: (R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid

Guidance literature:: (R)-3-methyl-2-[4'-(3-methyl-quinolin-2-yloxymethyl)-biphenyl-4-sulfonylamino]-butyric acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; methanol; for 72h;

With hydrogenchloride; In water; pH=3;