Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate

Base Information

• Chemical Name: Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate
• CAS No.: 144878-41-1
• Molecular Formula: C₂₄H₂₈O₈
• Molecular Weight: 444.482
• Mol file: 144878-41-1.mol

Synonyms:Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate

Chemical Property of Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate

There total 7 articles about Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

methyl (E)-3-(3,4-dimethoxyphenyl)acrylate (5396-64-5) → Methyl <5,6-dimethoxy-c-2-(methoxycarbonyl)-t-3-(3,4-dimethoxyphenyl)-r-1-indanyl>acetate (144878-41-1)

Guidance literature:

With trifluoroacetic acid; for 72h; Ambient temperature; other 3,4-dihydr(alk)oxycinnamic acids (or alkyl esters);

DOI:10.1055/s-1992-26278

Reference yield: 41.0%

methyl 3,4-dimethoxycinnamate (30461-77-9,30461-78-0,5396-64-5) + 3-methoxy-cinnamic acid methyl ester (15854-56-5) → 1-(3,4-Dimethoxy-phenyl)-5,6-dimethoxy-3-methoxycarbonylmethyl-indan-2-carboxylic acid methyl ester (144878-41-1) + (E)-3-{2-[1-(3,4-Dimethoxy-phenyl)-2-methoxycarbonyl-ethyl]-5-methoxy-phenyl}-acrylic acid methyl ester

Guidance literature:

With trifluoroacetic acid;

DOI:10.1248/cpb.30.3838

Reference yield:

methyl 3,4-dimethoxycinnamate (30461-77-9,30461-78-0,5396-64-5) → 1-(3,4-Dimethoxy-phenyl)-5,6-dimethoxy-3-methoxycarbonylmethyl-indan-2-carboxylic acid methyl ester (144878-41-1)

Guidance literature:

With trifluoroacetic acid; Yield given;

DOI:10.1248/cpb.30.3838

upstream raw materials:

methyl 3,4-dimethoxycinnamate

3-methoxy-cinnamic acid methyl ester

methyl (E)-3-(3,4-dimethoxyphenyl)acrylate

diazomethane

Downstream raw materials:

2-ethanol