1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

Base Information

Chemical Name:1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine
CAS No.:1027734-29-7
Molecular Formula:C₂₃H₂₅F₃N₆O
Molecular Weight:458.486
Hs Code.:

1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2<i>H</i>-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

Synonyms:1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

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Chemical Property of 1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

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Technology Process of 1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

There total 3 articles about 1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1774-47-6
trimethylsulfoxonium iodide

: 740832-30-8
1-(2,4-difluorophenyl)-2-(5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one

: 1027734-29-7
1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 25 - 30 ℃; for 1.5h;

1-(2,4-difluorophenyl)-2-(5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one; In dimethyl sulfoxide; at 80 - 90 ℃; for 6h;
DOI:10.1016/j.ejmech.2004.03.004

Reference yield:

: 3250-81-5
1-(4-fluorophenyl)-4-[2-(1H-tetrazol-5-yl)-ethyl]-piperazine

: 1027734-29-7
1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / sodium hydride / dimethylsulfoxide / 6 h / 25 - 60 °C

2.1: NaH / dimethylsulfoxide / 1.5 h / 25 - 30 °C

2.2: dimethylsulfoxide / 6 h / 80 - 90 °C

With sodium hydride; In dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2004.03.004

Reference yield:

: 126917-43-9,135133-19-6,138457-39-3
2-chloro-1-(2,4-difluorophenyl)propan-1-one

: 1027734-29-7
1-[2-(2-{1-[2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl}-2H-tetrazol-5-yl)-ethyl]-4-(4-fluoro-phenyl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / sodium hydride / dimethylsulfoxide / 6 h / 25 - 60 °C

2.1: NaH / dimethylsulfoxide / 1.5 h / 25 - 30 °C

2.2: dimethylsulfoxide / 6 h / 80 - 90 °C

With sodium hydride; In dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2004.03.004