SYK-368

Base Information

• Chemical Name: SYK-368
• CAS No.: 1415643-02-5
• Molecular Formula: C₂₈H₃₀N₂O₆
• Molecular Weight: 490.556

Synonyms:SYK-368

Chemical Property of SYK-368

Chemical Property:

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Technology Process of SYK-368

There total 3 articles about SYK-368 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C29H32N2O6 (1415642-98-6) → SYK-368 (1415643-02-5)

Guidance literature:

With 1-thiopropane; potassium tert-butylate; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1016/j.bmcl.2012.10.023

Reference yield:

17-N-benzyl-3-methoxynaltrexone → SYK-368 (1415643-02-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / methanol / 20 °C

1.2: 60 °C

2.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium chloride; sodium acetate / methanol / 20 °C

3.1: camphor-10-sulfonic acid / chloroform / 20 °C

4.1: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 130 °C

With 1-thiopropane; camphor-10-sulfonic acid; potassium tert-butylate; sodium acetate; potassium carbonate; ammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.023

Reference yield:

C25H27NO5 → SYK-368 (1415643-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium chloride; sodium acetate / methanol / 20 °C

2: camphor-10-sulfonic acid / chloroform / 20 °C

3: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 130 °C

With 1-thiopropane; camphor-10-sulfonic acid; potassium tert-butylate; sodium acetate; ammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.023

upstream raw materials:

C₂₉H₃₂N₂O₆

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