2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester
• CAS No.: 79416-09-4
• Molecular Formula: C₂₅H₃₀N₂O₁₀
• Molecular Weight: 518.521
• Mol file: 79416-09-4.mol

Synonyms:2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester

Chemical Property of 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester

There total 3 articles about 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzyl tosylate (4450-68-4) → 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester (79416-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetone / 2 h / Heating

2: 60percent aqueous acetic acid / 1 h / Heating

With acetic acid; In acetone;

DOI:10.1016/S0040-4039(01)92921-1

Reference yield:

benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(D-1-carboxyethyl)-α-D-glucopyranoside (15008-41-0) → 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester (79416-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetone / 2 h / Heating

2: 60percent aqueous acetic acid / 1 h / Heating

With acetic acid; In acetone;

DOI:10.1016/S0040-4039(01)92921-1

Reference yield:

2-((4aR,6S,7R,8R,8aS)-7-Acetylamino-6-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-propionic acid 4-nitro-benzyl ester (79416-08-3) → 2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-propionic acid 4-nitro-benzyl ester (79416-09-4)

Guidance literature:

With acetic acid; for 1h; Yield given; Heating;

DOI:10.1016/S0040-4039(01)92921-1

upstream raw materials:

2-((4aR,6S,7R,8R,8aS)-7-Acetylamino-6-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-propionic acid 4-nitro-benzyl ester

benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(D-1-carboxyethyl)-α-D-glucopyranoside

4-nitrobenzyl tosylate

Downstream raw materials:

Hexadecanoic acid (R)-2-{[2-({(2R,3R,4R,5R,6S)-5-acetylamino-6-benzyloxy-3-hydroxy-4-[1-(4-nitro-benzyloxycarbonyl)-ethoxy]-tetrahydro-pyran-2-ylmethyl}-amino)-ethoxy]-hydroxy-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

2-[(2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-4-yloxy]-propionic acid 4-nitro-benzyl ester