[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

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Chemical Name:[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester
CAS No.:128791-69-5
Molecular Formula:C₁₈H₂₂N₂O₇
Molecular Weight:378.382
Hs Code.:

Synonyms:[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

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Chemical Property of [(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

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Technology Process of [(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

There total 6 articles about [(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 128791-69-5
[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: p-TsOH*H₂O / CH₂Cl₂ / 1 h / Ambient temperature

2: aq. KOH / methanol / Ambient temperature

3: H₂ / 5percent Pd/C / ethanol / Ambient temperature

4: 78 percent / methanol; H₂O / 12 h / Ambient temperature

5: N₂O₄, NaOAc / CHCl₃ / 1 h / 0 °C

6: 1,2-dichloro-ethane / 3 h / Heating

With potassium hydroxide; hydrogen; sodium acetate; dinitrogen tetraoxide; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane;
DOI:10.1039/a700650k

Reference yield:

: (S)-3-Benzyloxycarbonylamino-4-(tetrahydro-pyran-2-yloxy)-butyric acid

: 128791-69-5
[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pd/C / ethanol / Ambient temperature

2: 78 percent / methanol; H₂O / 12 h / Ambient temperature

3: N₂O₄, NaOAc / CHCl₃ / 1 h / 0 °C

4: 1,2-dichloro-ethane / 3 h / Heating

With hydrogen; sodium acetate; dinitrogen tetraoxide; palladium on activated charcoal; In methanol; ethanol; chloroform; water; 1,2-dichloro-ethane;
DOI:10.1039/a700650k

Reference yield:

: (S)-3-Benzyloxycarbonylamino-4-(tetrahydro-pyran-2-yloxy)-butyric acid methyl ester

: 128791-69-5
[(S)-2-Oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. KOH / methanol / Ambient temperature

2: H₂ / 5percent Pd/C / ethanol / Ambient temperature

3: 78 percent / methanol; H₂O / 12 h / Ambient temperature

4: N₂O₄, NaOAc / CHCl₃ / 1 h / 0 °C

5: 1,2-dichloro-ethane / 3 h / Heating

With potassium hydroxide; hydrogen; sodium acetate; dinitrogen tetraoxide; palladium on activated charcoal; In methanol; ethanol; chloroform; water; 1,2-dichloro-ethane;
DOI:10.1039/a700650k