Technology Process of 6-bromo-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide
There total 9 articles about 6-bromo-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / palladium diacetate; triphenylphosphine / 4 h / 90 °C / 4560.31 Torr
2.1: sodium hydroxide; water / ethanol / 0.25 h
2.2: pH 6 - 7
3.1: triethylamine; HATU / N,N-dimethyl-formamide / 2 h
4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h
With
sodium hydroxide; N-Bromosuccinimide; water; triethylamine; HATU;
palladium diacetate; triphenylphosphine;
In
ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium bromate / ruthenium trichloride / water; acetonitrile / 1 h
2.1: sulfuric acid / acetic acid / 3 h / 100 °C / Sealed vial
2.2: pH 6 - 7
3.1: Oxalyl bromide / N,N-dimethyl-formamide / 1,2-dichloro-ethane / sealed vial
4.1: triethylamine / palladium diacetate; triphenylphosphine / 4 h / 90 °C / 4560.31 Torr
5.1: sodium hydroxide; water / ethanol / 0.25 h
5.2: pH 6 - 7
6.1: triethylamine; HATU / N,N-dimethyl-formamide / 2 h
7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h
With
sodium hydroxide; sodium bromate; N-Bromosuccinimide; Oxalyl bromide; water; triethylamine; HATU;
ruthenium trichloride; palladium diacetate; sulfuric acid; N,N-dimethyl-formamide; triphenylphosphine;
In
ethanol; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;