OXAZOLE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: OXAZOLE-5-CARBOXYLIC ACID
• CAS No.: 118994-90-4
• Molecular Formula: C4H3NO3
• Molecular Weight: 113.073
• Hs Code.: 2934999090
• Mol file: 118994-90-4.mol

Synonyms:1,3-Oxazole-5-carboxylicacid;5-Carboxyoxazole;1,3-oxazole-5-carboxylic acid;1,3-oxazole-5-carboxylic acid;

Chemical Property of OXAZOLE-5-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 195-197 °C
• Refractive Index: 1.517
• Boiling Point: 289.323 °C at 760 mmHg
• PKA: 2.39±0.10(Predicted)
• Flash Point: 128.778 °C
• PSA: 63.33000
• Density: 1.45 g/cm³
• LogP: 0.37280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Oxazole-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported.

Technology Process of OXAZOLE-5-CARBOXYLIC ACID

There total 1 articles about OXAZOLE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

oxazol-5-yl-carboxylic acid ethyl ester (118994-89-1) → 1,3-oxazole-5-carboxylic acid (118994-90-4)

Guidance literature:

With lithium hydroxide monohydrate; water; at 25 ℃; for 6.5h; Large scale;

Reference yield: 93.0%

1,3-oxazole-5-carboxylic acid (118994-90-4) + 4-fluoro-3-(oxazolo[4,5-b]pyridin-2-yl)benzenamine (1448807-27-9) → N-(4-fluoro-3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)oxazole-5-carboxamide (1448806-87-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 45 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.05.007

Reference yield: 80.0%

1,3-oxazole-5-carboxylic acid (118994-90-4) + 1-(4-(aminomethyl)-2-methoxybenzyl)-3-(4-methoxy-3-(pentyloxy)phenyl)-5-methyltetrahydropyrimidin-2(1H)-one → N-(3-methoxy-4-((3-(4-methoxy-3-(pentyloxy)phenyl)-5-methyl-2-oxotetrahydropyrimidin-1(2H)- yl)methyl)benzyl)oxazole-5-carboxamide

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

oxazol-5-yl-carboxylic acid ethyl ester

Downstream raw materials:

N-methyl-N-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]phenyl]-1,2-oxazole-5-carboxamide

C₂₂H₂₀N₆O₄

C₂₈H₃₈N₄O₆

N-(3-bromo-4-(2-(pyrrolidin-1-yl)ethoxy)phenethyl)oxazole-5-carboxamide

Refernces

• 1、 Jhaveri, Dishit P.,Osano, Mana,Wipf, Peter. "Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A". supporting information. p. 2215 - 2219. Retrieved 2020/04/09.
• 2、 -. "PROCESSES TO MAKE INDAZOLE DERIVATIVES". Page/Page column 21. . Retrieved 2016/12/22.