(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester
CAS No.:615569-03-4
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:

Synonyms:(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

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Chemical Property of (1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

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Technology Process of (1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

There total 4 articles about (1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255529-42-0
(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid benzyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 615569-03-4
(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

Guidance literature:: (1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 20h;

diazomethyl-trimethyl-silane; In methanol; toluene; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

: 1255529-39-5
(S)-3-cyclohexene-1-carboxylic acid benzyl ester

: 615569-03-4
(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 2 h / Cooling with ice

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 24 h / 70 °C

2.2: 24 h / 20 °C

2.3: 2 h

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

With sodium azide; hydrogen; ammonium chloride; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1255529-40-8
(1R,3S,6S)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester

: 615569-03-4
(1S,3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxycyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 24 h / 70 °C

1.2: 24 h / 20 °C

1.3: 2 h

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

With sodium azide; hydrogen; ammonium chloride; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;