1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate
CAS No.:1432674-51-5
Molecular Formula:C₁₈H₂₃F₂NO₄
Molecular Weight:355.382
Hs Code.:

Synonyms:1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

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Chemical Property of 1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

There total 3 articles about 1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: trans-1-tert-butyl 3-methyl 4-(4-chlorophenyl)piperidine-1,3-dicarboxylate

: 1432674-51-5
1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

Guidance literature:: trans-1-tert-butyl 3-methyl 4-(4-chlorophenyl)piperidine-1,3-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

With N-fluorobenzene sulfonamide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: C₁₃H₁₆ClNO₂

: 1432674-51-5
1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 205805-13-6
(±)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

: 1432674-51-5
1-tert-butyl 3-methyl 3-fluoro-4-(4-fluorophenyl)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 4.5 h / 0 °C / Reflux

1.2: 48 h / Reflux

2.1: triethylamine / dichloromethane / 20 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

3.2: 0 - 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;