(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

Base Information

Chemical Name:(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene
CAS No.:115205-88-4
Molecular Formula:C₂₅H₃₃NO₃
Molecular Weight:395.542
Hs Code.:

(4S,5S)-4-<benzyl(tert-butoxycarbonyl)amino>-5-hydroxy-2-methyl-6-phenyl-1-hexene

Synonyms:(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

Chemical Property:

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Technology Process of (4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

There total 6 articles about (4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 115205-86-2
(4S,5S)-4-(benzylamino)-5-hydroxy-2-methyl-6-phenyl-1-hexene

: 115205-88-4
(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

Guidance literature:: With triethylamine; In dichloromethane; for 4h;
DOI:10.1021/jo00251a042

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 115205-88-4
(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / conc. HCl / toluene / 4 h / Heating

2: 92 percent / toluene / 4 h / Heating

3: 1.) DIBAH, 2.) conc. HCl / 1.) toluene, hexane, 40 min, 2.) RT, 4 h

4: 84 percent / TiCl₄ / CH₂Cl₂ / 12 h / 0 - 20 °C

5: 88 percent / 50percent NaOH / ethanol / 10 h / Heating

6: 97 percent / Et₃N / CH₂Cl₂ / 4 h

With hydrogenchloride; sodium hydroxide; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo00251a042

Reference yield:

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 115205-88-4
(4S,5S)-4--5-hydroxy-2-methyl-6-phenyl-1-hexene

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / toluene / 4 h / Heating

2: 1.) DIBAH, 2.) conc. HCl / 1.) toluene, hexane, 40 min, 2.) RT, 4 h

3: 84 percent / TiCl₄ / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 88 percent / 50percent NaOH / ethanol / 10 h / Heating

5: 97 percent / Et₃N / CH₂Cl₂ / 4 h

With hydrogenchloride; sodium hydroxide; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo00251a042