1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Base Information

Chemical Name:1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile
CAS No.:1428130-75-9
Molecular Formula:C₂₂H₁₆Cl₂FN₃O
Molecular Weight:428.293
Hs Code.:

Synonyms:1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

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Chemical Property of 1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

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Technology Process of 1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

There total 6 articles about 1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 557-21-1
zinc(II) cyanide

: 1428130-71-5
1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-4-iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

: 1428130-75-9
1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1428129-52-5
3-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-1,2,3-oxathiazolidine 2,2-dioxide

: 1428130-75-9
1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1428129-53-6
2-({5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}amino)ethanol

: 1428130-75-9
1-{5-chloro-2-[(4-chloro-2-fluorobenzyl)oxy]benzyl}-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; thionyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: sodium periodate; ruthenium(III) trichloride hydrate / water; acetonitrile / 7 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C

3.2: 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; ruthenium(III) trichloride hydrate; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;