6-amino-2,3-difluorobenzamide

Base Information

Chemical Name:6-amino-2,3-difluorobenzamide
CAS No.:1116228-26-2
Molecular Formula:C₇H₆F₂N₂O
Molecular Weight:172.134
Hs Code.:

Synonyms:6-amino-2,3-difluorobenzamide

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Chemical Property of 6-amino-2,3-difluorobenzamide

Chemical Property:

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Technology Process of 6-amino-2,3-difluorobenzamide

There total 5 articles about 6-amino-2,3-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 442134-72-7
2,3-difluoro-6-aminobenzoic acid

: 1116228-26-2
6-amino-2,3-difluorobenzamide

Guidance literature:: With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dioxanes; at 20 ℃; for 24h;

Reference yield:

: 144298-04-4
(3,4-difluorophenyl)-carbamic acid-tert-butyl ester

: 1116228-26-2
6-amino-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 3 h / -78 °C

1.2: 1 h / -78 °C

2.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C

4.1: N-hydroxybenzotriazole ammonium salt; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With N-hydroxybenzotriazole ammonium salt; lithium hydroxide monohydrate; water; tert.-butyl lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1092513-08-0
ethyl 6-(tert-butoxycarbonylamino)-2,3-difluorobenzoate

: 1116228-26-2
6-amino-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C

3: N-hydroxybenzotriazole ammonium salt; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With N-hydroxybenzotriazole ammonium salt; lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;