2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester

Base Information

• Chemical Name: 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester
• CAS No.: 195063-49-1
• Molecular Formula: C₅₇H₆₀Cl₃NO₁₁
• Molecular Weight: 1041.46
• Mol file: 195063-49-1.mol

Synonyms:2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester

Chemical Property of 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester

There total 1 articles about 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

trichloroacetonitrile (545-06-2) + (3S,4S,5R,6R)-3-Benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ol → 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester (195063-49-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1080/07328309708006545

Reference yield: 65.0%

(2R,3R,4S,5S,6R)-6-((2R,3R,4S,5S,6S)-6-Allyloxy-5-benzyloxy-2-benzyloxymethyl-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzyloxy-2-benzyloxymethyl-4-methoxy-tetrahydro-pyran-3-ol (194594-71-3) + 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester (195063-49-1) → allyl O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-[(1->4)-O-(2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranosyl)]2-(1->4)-2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranoside (195063-62-8)

Guidance literature:

With molecular sieve; triethylsilyl trifluoromethyl sulfonate; In dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1080/07328309708006545

Reference yield: 56.0%

allyl O-(2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranosyl)-[(1->4)-O-(2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranosyl)]2-(1->4)-2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranoside (194594-74-6) + 2,2,2-Trichloro-acetimidic acid (2R,3S,4S,5R,6R)-3-benzyloxy-6-benzyloxymethyl-4-methoxy-5-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester (195063-49-1) → allyl O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-[(1->4)-O-(2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranosyl)]4-(1->4)-2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranoside

Guidance literature:

With molecular sieve; triethylsilyl trifluoromethyl sulfonate; In dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1080/07328309708006545

upstream raw materials:

trichloroacetonitrile

Downstream raw materials:

allyl O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-[(1->4)-O-(2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranosyl)]2-(1->4)-2,6-di-O-benzyl-3-O-methyl-α-D-mannopyranoside