Technology Process of (S)-3--1-(hydroxymethyl)cyclopentene
There total 9 articles about (S)-3--1-(hydroxymethyl)cyclopentene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
diethyl ether; toluene;
at 0 ℃;
for 2h;
DOI:10.1021/jo00061a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 89 percent / K3PO4 / nitromethane / 72 h / Ambient temperature
2: 89 percent / HCl / ethyl acetate / 24 h / Ambient temperature
3: 97 percent / tetrahydrofuran / 20 h / Ambient temperature
4: 97 percent / KHMDS / tetrahydrofuran / 1 h / -78 °C
5: 85 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h
6: 1.) Et3N, DMAP, methanesulfonyl chloride (MsCl), 2.) KOtBu / 1.) THF, 3 h, 0 deg C, 2.) THF, 15 min, 0 deg C
7: 94 percent / DIBALH / toluene; diethyl ether / 2 h / 0 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; potassium phosphate; potassium tert-butylate; potassium hexamethylsilazane; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; nitromethane; ethyl acetate; toluene;
DOI:10.1021/jo00061a006
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) Et3N, DMAP, methanesulfonyl chloride (MsCl), 2.) KOtBu / 1.) THF, 3 h, 0 deg C, 2.) THF, 15 min, 0 deg C
2: 94 percent / DIBALH / toluene; diethyl ether / 2 h / 0 °C
With
dmap; potassium tert-butylate; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
diethyl ether; toluene;
DOI:10.1021/jo00061a006
