N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Base Information

• Chemical Name: N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide
• CAS No.: 1380665-44-0
• Molecular Formula: C₂₉H₃₇FN₆O₆
• Molecular Weight: 584.648

Synonyms:N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Chemical Property of N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

There total 7 articles about N₂-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester (1380665-18-8) → N2-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-44-0)

Guidance literature:

Multi-step reaction with 9 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

7: dichloromethane / 1 h / Inert atmosphere; Reflux

8: hydrogenchloride / water; tetrahydrofuran

9: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; hydrogen; sodium carbonate; potassium carbonate; Dess-Martin periodane; triethylamine; HATU; potassium iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

C26H30FN5O7 (1380665-27-9) → N2-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

2: dichloromethane / 1 h / Inert atmosphere; Reflux

3: hydrogenchloride / water; tetrahydrofuran

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-7-formyl-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N',N'-dimethyl-ethanediamide (1380665-22-4) → N2-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide (1380665-44-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

2: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

3: dichloromethane / 1 h / Inert atmosphere; Reflux

4: hydrogenchloride / water; tetrahydrofuran

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

C₂₆H₃₀FN₅O₇

N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-isocyanato-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide

Downstream raw materials:

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(4-morpholinyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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