4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

Base Information

Chemical Name:4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol
CAS No.:850785-79-4
Molecular Formula:C₂₂H₂₀BrClO₇
Molecular Weight:511.754
Hs Code.:

Synonyms:4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

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Chemical Property of 4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

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Technology Process of 4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

There total 2 articles about 4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 850785-78-3
2,3-bis(bromomethyl)-4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene

: 850785-79-4
4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

Guidance literature:: 2,3-bis(bromomethyl)-4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene; With potassium carbonate; acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jo047751u

Reference yield:

: 198905-84-9
1-chloro-2,3-dimethyl-6,7-methylenedioxy-4-(3,4,5-trimethoxyphenyl)naphthalene

: 850785-79-4
4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / N-bromosuccinimide; AIBN / benzene / 1 h / Heating

2.1: AcOH; K₂CO₃ / dimethylformamide / 2 h / 20 °C

2.2: 82 percent / KOH / dimethylformamide; methanol; H₂O / 2 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo047751u

Reference yield:

: 850785-79-4
4-(2-bromo-3,4,5-trimethoxyphenyl)-1-chloro-6,7-methylenedioxynaphthalene-2,3-diyldimethanol

: 6258-41-9
5-(3,4,5-Trimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 67 percent / SmI₂; HMPA / tetrahydrofuran / 2 h / 20 °C

2.1: Bu₂SnO / toluene / 2 h / Heating

2.2: 69 percent / toluene / 20 h

3.1: PDC / dimethylformamide / 4 h / 20 °C

4.1: I₂; KOH; MeOH / 16 h / 20 °C

4.2: aq. HCl / methanol

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; dipyridinium dichromate; samarium diiodide; iodine; di(n-butyl)tin oxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo047751u