(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1408097-79-9
Molecular Formula:C₁₈H₂₃IN₂O₅
Molecular Weight:474.296
Hs Code.:

Synonyms:(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

There total 1 articles about (R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 77317-55-6
methyl 2-amino-5-iodobenzoate

: 1408097-79-9
(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: N-(tert-butoxycarbonyl)-D-proline; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

methyl 2-amino-5-iodobenzoate; In tetrahydrofuran; at 0 - 20 ℃; for 51h; Inert atmosphere; Reflux;
DOI:10.1039/c2ob26132d

Reference yield:

: 1408097-79-9
(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

: 1408097-91-5
C₁₃H₁₅IN₂O₃

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/c2ob26132d

Reference yield:

: 1408097-79-9
(R)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

: 1408097-92-6
C₅₄H₅₆I₄N₈O₁₁

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob26132d