(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

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Chemical Name:(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine
CAS No.:1443791-19-2
Molecular Formula:C₃₇H₄₄N₄O₅S
Molecular Weight:656.846
Hs Code.:

Synonyms:(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

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Chemical Property of (S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

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Technology Process of (S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

There total 8 articles about (S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: C₃₈H₄₆N₄O₅S

: 1443791-19-2
(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

Guidance literature:: C₃₈H₄₆N₄O₅S; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 1443792-06-0
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

: 1443791-19-2
(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate decahydrate / water / 5 h / Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 0.83 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogen; palladium on activated charcoal / ethyl acetate

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

4.2: 5 h

5.1: HATU; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

6.2: pH 1

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate decahydrate; palladium on activated charcoal; water; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1443792-08-2
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)propanoate

: 1443791-19-2
(S)-(2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-propanoyl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium on activated charcoal / ethyl acetate

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

2.2: 5 h

3.1: HATU; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

4.2: pH 1

With palladium on activated charcoal; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;