2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile
• CAS No.: 340167-21-7
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.276
• Mol file: 340167-21-7.mol

Synonyms:2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile

Chemical Property of 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile

There total 1 articles about 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

Z α-nitrobenzylidene acetone (55902-35-7) + (E)-3-aminocrotononitrile (763-33-7) → 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile (340167-21-7)

Guidance literature:

With acetic acid; at 20 ℃;

DOI:10.1007/s10593-005-0214-4

Reference yield: 89.0%

2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile (340167-21-7) → 2,6-dimethyl-5-nitro-4-phenyl-nicotinonitrile (292617-98-2)

Guidance literature:

With chromium(III) oxide; acetic acid; In water; at 60 - 100 ℃;

DOI:10.1016/S0040-4020(00)01162-5

Reference yield:

2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydro-pyridine-3-carbonitrile (340167-21-7) → 3-cyano-1,2,6-trimethyl-5-nitro-4-phenylpyridinium trifluoromethanesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / chromium oxide; acetic acid / H₂O / 60 - 100 °C

2: 79 percent / 1,2-dichloro-ethane / 30 h / 100 °C

With chromium(III) oxide; acetic acid; In water; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4020(00)01162-5

upstream raw materials:

Z α-nitrobenzylidene acetone

(E)-3-aminocrotononitrile

Downstream raw materials:

2,6-dimethyl-5-nitro-4-phenyl-nicotinonitrile