ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

Base Information

Chemical Name:ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate
CAS No.:638214-41-2
Molecular Formula:C₂₈H₃₀F₃NO₃S
Molecular Weight:517.612
Hs Code.:

Synonyms:ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

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Chemical Property of ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

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Technology Process of ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

There total 10 articles about ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-37-6
2-(1-chloropentyl)-6-[4-(trifluoromethyl)phenyl]pyridine

: 343322-82-7
ethyl [(4-mercapto-2-methylphenyl)oxy]acetate

: 638214-41-2
ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

Guidance literature:: With caesium carbonate; In tetrahydrofuran; at 20 - 66 ℃; for 78h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638214-41-2
ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2: thionyl chloride / dichloromethane / 3 h / 20 °C

3: caesium carbonate / tetrahydrofuran / 78 h / 20 - 66 °C

With thionyl chloride; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki Coupling;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638214-41-2
ethyl ({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)thio]phenyl}oxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: thionyl chloride / dichloromethane / 3 h / 20 °C

6.1: caesium carbonate / tetrahydrofuran / 78 h / 20 - 66 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; dichloromethane; chloroform; water; 3.1: Suzuki Coupling;