[3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone

Base Information

• Chemical Name: [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone
• CAS No.: 737800-10-1
• Molecular Formula: C₅₄H₅₈Cl₂O₈Si
• Molecular Weight: 934.041
• Mol file: 737800-10-1.mol

Synonyms:[3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone

Chemical Property of [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone

There total 6 articles about [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

[3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanol (1026582-55-7) → [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone (737800-10-1)

Guidance literature:

With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In toluene;

DOI:10.1016/j.tetlet.2004.05.063

Reference yield:

prenyl bromide (870-63-3) → [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone (737800-10-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-BuLi / -78 °C

1.2: 78 percent / 1,2-dimethoxy-ethane / 0 °C

2.1: n-BuLi / -78 °C

2.2: 62 percent / 1,2-dimethoxy-ethane / 0 °C

3.1: 86 percent / LiAlH₄ / tetrahydrofuran

4.1: 99 percent / imidazole / dimethylformamide

5.1: MeI / 40 °C

5.2: NaBH₄ / methanol; tetrahydrofuran

5.3: 69 percent / aq. AcOH / tetrahydrofuran

6.1: 99 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

7.1: 69 percent / IBX; DMSO / toluene

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; dimethyl sulfoxide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetlet.2004.05.063

Reference yield:

[4,6-bis-benzyloxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-(3-methyl-but-2-enyl)-phenyl]-methanol (737800-16-7) → [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanone (737800-10-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 99 percent / imidazole / dimethylformamide

2.1: MeI / 40 °C

2.2: NaBH₄ / methanol; tetrahydrofuran

2.3: 69 percent / aq. AcOH / tetrahydrofuran

3.1: 99 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

4.1: 69 percent / IBX; DMSO / toluene

With 1H-imidazole; n-butyllithium; dimethyl sulfoxide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetlet.2004.05.063

upstream raw materials:

[3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanol

prenyl bromide

[4,6-bis-benzyloxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-(3-methyl-but-2-enyl)-phenyl]-methanol

4,6-bis-benzyloxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-(3-methyl-but-2-enyl)-benzoic acid methyl ester