(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

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Chemical Name:(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion
CAS No.:131285-53-5
Molecular Formula:C₂₄H₃₄N₄O₆
Molecular Weight:474.557
Hs Code.:

Synonyms:(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

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Chemical Property of (+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

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Technology Process of (+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

There total 6 articles about (+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 131285-51-3
(-)-1-<(2,6-dibenzyloxypyrimidin-4-yl)-(3-dimethylamino-4-methylphenyl)-amino>-2,3:4,5-bis-O-(1-methylethyliden)-1-deoxy-D-ribitol

: 131285-53-5
(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 760 Torr;
DOI:10.1002/ardp.19903231012

Reference yield:

: 50-69-1
D-ribose

: 131285-53-5
(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

Guidance literature:: Multi-step reaction with 5 steps

1: 2) NaBH₃CN / 1) EtOH, reflux, 1 h, 2) NH₄OAc/HCl-buffer (pH 3.5), 16 h

2: 41 percent / p-TsOH*H₂O / acetone / 1 h

3: 35 percent / KHCO₃, tetrabutylammonium bromide / toluene / 16 h / 100 °C

4: 76 percent / toluene / 16 h / Heating

5: 100 percent / H₂ / 10percent Pd-C / methanol / 2 h / 760 Torr

With tetrabutylammomium bromide; hydrogen; sodium cyanoborohydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; acetone; toluene;
DOI:10.1002/ardp.19903231012

Reference yield:

: 6406-67-3
N¹,N¹,6-trimethylbenzene-1,3-diamine

: 131285-53-5
(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

Guidance literature:: Multi-step reaction with 5 steps

1: 2) NaBH₃CN / 1) EtOH, reflux, 1 h, 2) NH₄OAc/HCl-buffer (pH 3.5), 16 h

2: 41 percent / p-TsOH*H₂O / acetone / 1 h

3: 35 percent / KHCO₃, tetrabutylammonium bromide / toluene / 16 h / 100 °C

4: 76 percent / toluene / 16 h / Heating

5: 100 percent / H₂ / 10percent Pd-C / methanol / 2 h / 760 Torr

With tetrabutylammomium bromide; hydrogen; sodium cyanoborohydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; acetone; toluene;
DOI:10.1002/ardp.19903231012