2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Chemical Name:2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid
CAS No.:139347-03-8
Molecular Formula:C₂₁H₂₅N₆O₇P
Molecular Weight:504.439
Hs Code.:

Synonyms:2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Chemical Property of 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Technology Process of 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

There total 6 articles about 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139347-34-5
methyl D,L-2-formamido-4-(diethoxyphosphinyl)butanoate

: 139347-03-8
2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: HCl (sat. sol. in MeOH), SOCl₂ / 18 h / Ambient temperature

2: 30 percent / Et₃N / CH₂Cl₂

3: 98 percent / H₂ / 5percent Pd/C / methanol / 20 h / 2280 Torr

4: acetic acid / 17 h / Ambient temperature

5: BH₃*NEt₃ / acetic acid / 0.33 h / 65 °C

6: 1N NaOH / 0.5 h / 85 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; triethylamine-borane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00087a012

Reference yield:

: 139347-35-6
methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

: 139347-03-8
2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 5percent Pd/C / methanol / 20 h / 2280 Torr

2: acetic acid / 17 h / Ambient temperature

3: BH₃*NEt₃ / acetic acid / 0.33 h / 65 °C

4: 1N NaOH / 0.5 h / 85 °C

With sodium hydroxide; triethylamine-borane; hydrogen; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1021/jm00087a012

Reference yield:

: 139405-64-4
methyl D,L-2-amino-4-(diethoxyphosphinyl)butanoate hydrochloride

: 139347-03-8
2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent / Et₃N / CH₂Cl₂

2: 98 percent / H₂ / 5percent Pd/C / methanol / 20 h / 2280 Torr

3: acetic acid / 17 h / Ambient temperature

4: BH₃*NEt₃ / acetic acid / 0.33 h / 65 °C

5: 1N NaOH / 0.5 h / 85 °C

With sodium hydroxide; triethylamine-borane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00087a012