(2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester

Base Information

• Chemical Name: (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester
• CAS No.: 184636-27-9
• Molecular Formula: C₁₆H₂₀F₃NO₅S
• Molecular Weight: 395.4

Synonyms:(2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester

Chemical Property of (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester

Chemical Property:

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Technology Process of (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester

There total 1 articles about (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(+)-(R)-ethyl p-tolyl sulfoxide (1519-40-0) + methyl 2-(N-ethoxycarbonylimino)-3,3,3-trifluoropropionate (161083-22-3) → (2R,3S)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester + (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester (184636-27-9) + (2S,3S)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester + (2S,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester (184636-26-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;

Reference yield: 95.0%

trifluoroacetic anhydride (407-25-0) + (2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester (184636-27-9) → (2R,3R)-2-Ethoxycarbonylamino-3-p-tolylsulfanyl-2-trifluoromethyl-butyric acid methyl ester (184636-37-1)

Guidance literature:

With sodium iodide; In acetone; at -20 ℃; for 0.0833333h;

Reference yield:

(2R,3R)-2-Ethoxycarbonylamino-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyric acid methyl ester (184636-27-9) → C16H19ClF3NO4S

Guidance literature:

With 2,4,6-trimethyl-pyridine; oxalyl dichloride; In dichloromethane; at -50 ℃;

DOI:10.1016/S0040-4039(01)00651-7

upstream raw materials:

(+)-(R)-ethyl p-tolyl sulfoxide

methyl 2-(N-ethoxycarbonylimino)-3,3,3-trifluoropropionate

Downstream raw materials:

(2R,3R)-2-Ethoxycarbonylamino-3-p-tolylsulfanyl-2-trifluoromethyl-butyric acid methyl ester

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