N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

Base Information

Chemical Name:N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate
CAS No.:107716-42-7
Molecular Formula:C₃₀H₃₉N₈O₁₄P
Molecular Weight:766.659
Hs Code.:

N-<4-<N-<2-<N-(2-amino-4-oxo-6-methylpyrimidin-5-yl)-N-<(2'-deoxyuridin-5-yl)methyl>amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

Synonyms:N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

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Chemical Property of N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

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Technology Process of N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

There total 8 articles about N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 107716-42-7
N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / sodium cyanoborohydride, bromocresol green, acetic acid / ethanol / 48 h / Ambient temperature

2: 91 percent / sodium cyanoborohydride, bromocresol green, aq. acetic acid / acetonitrile / 1 h / Ambient temperature

3: 80 percent / hydrogen, HCl / palladium on carbon / ethanol / 3 h / 2482.3 Torr

4: aq. acetic acid / 1.) 0 deg C, 2.) room temperature, 17 h

5: 80 percent / pyridine / 1 h / Ambient temperature

6: 20 percent / dimethylformamide / 24 h / 90 - 100 °C

7: 42 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

8: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With hydrogenchloride; sodium hydroxide; hydrogen; bromocresol green; copper; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; acetylacetone; zinc; palladium on activated charcoal; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00119a012

Reference yield:

: 115827-03-7
diethyl N--L-glutamate

: 107716-42-7
N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / hydrogen, HCl / palladium on carbon / ethanol / 3 h / 2482.3 Torr

2: aq. acetic acid / 1.) 0 deg C, 2.) room temperature, 17 h

3: 80 percent / pyridine / 1 h / Ambient temperature

4: 20 percent / dimethylformamide / 24 h / 90 - 100 °C

5: 42 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

6: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With hydrogenchloride; sodium hydroxide; hydrogen; copper; sodium hydrogencarbonate; acetylacetone; zinc; palladium on activated charcoal; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a012

Reference yield:

: 70280-70-5
diethyl N--L-glutamate

: 107716-42-7
N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / sodium cyanoborohydride, bromocresol green, aq. acetic acid / acetonitrile / 1 h / Ambient temperature

2: 80 percent / hydrogen, HCl / palladium on carbon / ethanol / 3 h / 2482.3 Torr

3: aq. acetic acid / 1.) 0 deg C, 2.) room temperature, 17 h

4: 80 percent / pyridine / 1 h / Ambient temperature

5: 20 percent / dimethylformamide / 24 h / 90 - 100 °C

6: 42 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

7: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With hydrogenchloride; sodium hydroxide; hydrogen; bromocresol green; copper; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; acetylacetone; zinc; palladium on activated charcoal; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00119a012