(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:204977-64-0
Molecular Formula:C₃₆H₄₉N₃O₆Si
Molecular Weight:647.887
Hs Code.:

(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Synonyms:(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 7 articles about (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 204977-63-9
(R)-5-Acetoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 204977-64-0
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 2h; Ambient temperature;

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 204977-64-0
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium sulfate / 6 h / Heating

2: 90 percent / TMSOTf / 1,2-dichloro-ethane / 2 h / Ambient temperature

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;

Reference yield:

: 204977-57-1
(S)-2-Hydroxy-3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonylamino)-propionic acid methyl ester

: 204977-64-0
(R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-oxazolidine-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / p-TsOH / toluene / 8 h / Heating

2: Amberlite IRA-400 (OH^- form) / methanol / 24 h / Ambient temperature

3: imidazole / dimethylformamide / 3 h / Ambient temperature

4: aq. NaOH / methanol; H₂O / 4 h / Ambient temperature

5: pyridine / ethyl acetate / 2 h / Heating

6: 90 percent / TMSOTf / 1,2-dichloro-ethane / 2 h / Ambient temperature

With pyridine; 1H-imidazole; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; Amberlite IRA-400 (OH^- form); toluene-4-sulfonic acid; In methanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;