(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

Base Information

Chemical Name:(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine
CAS No.:914935-67-4
Molecular Formula:C₂₉H₃₅F₂NO₂Si
Molecular Weight:495.685
Hs Code.:

Synonyms:(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

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Chemical Property of (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

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Technology Process of (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

There total 4 articles about (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 914935-66-3
[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3,4-difluorophenyl]methanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 914935-67-4
(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 18 - 25 ℃; for 15h;

Reference yield:

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 914935-67-4
(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 13.75 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran; ethanol / 12 h / 10 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 12.25 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm501174m

Reference yield:

: 914935-65-2
2-((2R,6S)-2,6-dimethylmorpholin-4-yl)-3,4-difluorobenzoic acid

: 914935-67-4
(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran; ethanol / 12 h / 10 °C / Reflux

2: 1H-imidazole / dichloromethane / 12.25 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm501174m