tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

Base Information

Chemical Name:tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane
CAS No.:502430-41-3
Molecular Formula:C₂₁H₃₆O₅Si
Molecular Weight:396.599
Hs Code.:

Synonyms:tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

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Chemical Property of tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

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Technology Process of tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

There total 6 articles about tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5,5-dimethoxy-hex-2-en-1-ol

: 502430-41-3
tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0 °C

2.1: (DHQ)2PYR; K₂OsO₄; MeSO₂NH₂ / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 4 °C

2.2: PPTS / methanol

2.3: NaH / tetrahydrofuran / 0 °C

3.1: aq. HCl / CH₂Cl₂ / 0 °C

3.2: 2,6-lutidine / CH₂Cl₂ / -78 °C

With hydrogenchloride; potassium osmate(VI); (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); methanesulfonamide; sodium hydride; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol034035q

Reference yield:

: 29267-46-7
3,3-bismethoxybutyric acid methyl ester

: 502430-41-3
tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: LiAlH₄ / tetrahydrofuran / 0 °C

2.1: PDC; 4 Angstroem molecular sieves / CH₂Cl₂

3.1: NaH / tetrahydrofuran

4.1: DIBAL / CH₂Cl₂ / -78 °C

5.1: NaH / tetrahydrofuran / 0 °C

6.1: (DHQ)2PYR; K₂OsO₄; MeSO₂NH₂ / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 4 °C

6.2: PPTS / methanol

6.3: NaH / tetrahydrofuran / 0 °C

7.1: aq. HCl / CH₂Cl₂ / 0 °C

7.2: 2,6-lutidine / CH₂Cl₂ / -78 °C

With hydrogenchloride; potassium osmate(VI); lithium aluminium tetrahydride; dipyridinium dichromate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); methanesulfonamide; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol034035q

Reference yield:

: 502430-58-2
3,3-dimethoxybityraldehyde

: 502430-41-3
tert-butyl-[(4S)-methoxy-(5S)-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-furan-2-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran

2.1: DIBAL / CH₂Cl₂ / -78 °C

3.1: NaH / tetrahydrofuran / 0 °C

4.1: (DHQ)2PYR; K₂OsO₄; MeSO₂NH₂ / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 4 °C

4.2: PPTS / methanol

4.3: NaH / tetrahydrofuran / 0 °C

5.1: aq. HCl / CH₂Cl₂ / 0 °C

5.2: 2,6-lutidine / CH₂Cl₂ / -78 °C

With hydrogenchloride; potassium osmate(VI); (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); methanesulfonamide; sodium hydride; diisobutylaluminium hydride; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol034035q