Boc-Arg(Boc)2OH

Base Information

• Chemical Name: Boc-Arg(Boc)2OH
• CAS No.: 108787-91-3
• Molecular Formula: C₂₁H₃₈N₄O₈
• Molecular Weight: 474.555
• Mol file: 108787-91-3.mol

Synonyms:Boc-Arg(Boc)2OH

Chemical Property of Boc-Arg(Boc)2OH

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Arg(Boc)2OH

There total 23 articles about Boc-Arg(Boc)2OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2C5H11N2O2(1-)*2Cu(2+)*2Cl(1-) + di-tert-butyl dicarbonate (24424-99-5) + N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) → Boc-Arg(Boc)2OH (108787-91-3)

Guidance literature:

2C₅H₁₁N₂O₂^(1-)*2Cu⁽²⁺⁾*2Cl^(1-); N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine; With formamide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 5h;

di-tert-butyl dicarbonate; With ethylene diamine tetraacetic acid tetrasodium salt; sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 12h; Further stages.;

DOI:10.1016/j.tet.2003.11.031

Reference yield: 78.0%

N2-(tert-butoxycarbonyl)-L-ornithine (21887-64-9) + N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) → Boc-Arg(Boc)2OH (108787-91-3)

Guidance literature:

With diisopropylamine; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jacs.8b01933

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + t-butyloxycarbonyl-L-arginine (13726-76-6,78603-12-0) → Boc-Arg(Boc)2OH (108787-91-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃; for 42h;

DOI:10.1371/journal.pone.0107994

upstream raw materials:

di-tert-butyl dicarbonate

N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

N₂-(tert-butoxycarbonyl)-L-ornithine

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

Downstream raw materials:

C₃₆H₄₇N₅O₈

C₃₆H₄₇N₅O₉

C₅₉H₈₃N₇O₁₅

Refernces

• 1、 Dunham, Noah P.,Chang, Wei-Chen,Mitchell, Andrew J.,Martinie, Ryan J.,Zhang, Bo,Bergman, Jonathan A.,Rajakovich, Lauren J.,Wang, Bo,Silakov, Alexey,Krebs, Carsten,Boal, Amie K.,Bollinger, J. Martin. "Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance". . p. 7116 - 7126. Retrieved 2018.
• 2、 Prati, Federica,Goldman-Pinkovich, Adele,Lizzi, Federica,Belluti, Federica,Koren, Roni,Zilberstein, Dan,Bolognesi, Maria Laura. "Quinone-amino acid conjugates targeting leishmania amino acid transporters". . . Retrieved 2014.
• 3、 Jovanovic, Milos,Radivojevic, Jelena,O'Connor, Kevin,Blagojevic, Stevan,Begovic, Biljana,Lukic, Vera,Nikodinovic-Runic, Jasmina,Savic, Vladimir. "Rhamnolipid inspired lipopeptides effective in preventing adhesion and biofilm formation of Candida albicans". supporting information. p. 209 - 217. Retrieved 2019/03/23.