L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate)

Base Information

Chemical Name:L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate)
CAS No.:70637-28-4
Molecular Formula:C₂HF₃O₂*C₂₂H₂₈N₂O₃
Molecular Weight:482.5
Hs Code.:
Mol file:70637-28-4.mol

Synonyms:(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt

Suppliers and Price of L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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ChemScene
L-Phenylalanine,L-leucyl-,phenylmethylestermonotrifluoroacetate
1g
$ 450.00

Total 8 raw suppliers

Chemical Property of L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

L-Phenylalanine,L-leucyl-,phenylmethylestermonotrifluoroacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate)

There total 3 articles about L-Phenylalanine, L-leucyl-, phenylmethyl ester (monotrifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 140834-91-9,70637-26-2
(S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate

: 76-05-1
trifluoroacetic acid

: 70637-28-4
(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt

Guidance literature:: at 20 ℃; for 3h; Inert atmosphere; Green chemistry;
DOI:10.1039/c7gc00247e

Reference yield:

: 2462-32-0
L-phenylalanine benzyl ester hydrochloride

: 70637-28-4
(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 16 h / 0 - 20 °C / Inert atmosphere; Green chemistry

2: 3 h / 20 °C / Inert atmosphere; Green chemistry

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
DOI:10.1039/c7gc00247e

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 70637-28-4
(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: dichloromethane / 5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b01201