(2-Methylimidazo[1,2-a]pyridin-3-yl)methanol

Base Information

• Chemical Name: (2-Methylimidazo[1,2-a]pyridin-3-yl)methanol
• CAS No.: 30489-44-2
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.1885
• Hs Code.: 2933990090
• European Community (EC) Number: 694-879-3
• DSSTox Substance ID: DTXSID90427621
• Wikidata: Q82240279
• Mol file: 30489-44-2.mol

Synonyms:(2-methylimidazo[1,2-a]pyridin-3-yl)methanol;30489-44-2;{2-methylimidazo[1,2-a]pyridin-3-yl}methanol;MFCD07368506;3-(Hydroxymethyl)-2-methylimidazo[1,2-a]pyridine;2-methylimidazo[1,2-a]pyridine-3-methanol;SCHEMBL859998;(2-Methyl-lH-iMidazo[1,2-a]pyridin-3-yl)Methanol;DTXSID90427621;SEKFTKBRYHPGEI-UHFFFAOYSA-N;AKOS000348756;BG-0710;AM803668;CS-0450787;FT-0686335;J-500870;(2-Methylimidazo[1,2-a]pyridin-3-yl)methanol, AldrichCPR

Chemical Property of (2-Methylimidazo[1,2-a]pyridin-3-yl)methanol

Chemical Property:

• Refractive Index: 1.622
• PKA: 14.11±0.10(Predicted)
• PSA: 37.53000
• Density: 1.22 g/cm³
• LogP: 1.13500
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.079312947
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%,99%, ^*data from raw suppliers

{2-methylimidazo[1,2-a]pyridin-3-yl}methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CC=CC2=N1)CO

Technology Process of (2-Methylimidazo[1,2-a]pyridin-3-yl)methanol

There total 4 articles about (2-Methylimidazo[1,2-a]pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (2549-19-1) → 3-(hydroxymethyl)-2-methylimidazo<1,2-a>pyridine (30489-44-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1) 0 deg C to 22 deg C, 2) 22 deg C, 1 h;

DOI:10.1021/jm00129a028

Reference yield:

2-metilimidazo<1,2-a>piridin-3-carbossaldeide (30384-93-1) → 3-(hydroxymethyl)-2-methylimidazo<1,2-a>pyridine (30489-44-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃;

Reference yield:

2-aminopyridine (504-29-0) → 3-(hydroxymethyl)-2-methylimidazo<1,2-a>pyridine (30489-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / NaHCO₃ / 1,2-dimethoxy-ethane / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1) 0 deg C to 22 deg C, 2) 22 deg C, 1 h

With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane;

DOI:10.1021/jm00129a028

upstream raw materials:

ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate

2-aminopyridine

2-metilimidazo<1,2-a>piridin-3-carbossaldeide

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