(S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide

Base Information

• Chemical Name: (S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide
• CAS No.: 1176919-44-0
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.39
• Mol file: 1176919-44-0.mol

Synonyms:(S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide

Chemical Property of (S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide

There total 1 articles about (S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-tert-leucinol (112245-13-3) + (E)-3-(2,4-dimethoxyphenyl)prop-2-enoyl chloride → (S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide (1176919-44-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4.5h;

DOI:10.1016/j.tetasy.2009.04.005

Reference yield: 55.0%

(S)-trans-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-2,4-dimethoxycinnamamide (1176919-44-0) → (S)-trans-2-(2,4-dimethoxyphenyl)-(4-tert-butyloxazoline-2-yl)ethene (1176919-45-1)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at -5 - 20 ℃;

DOI:10.1016/j.tetasy.2009.04.005

upstream raw materials:

(S)-tert-leucinol

Downstream raw materials:

(S)-trans-2-(2,4-dimethoxyphenyl)-(4-tert-butyloxazoline-2-yl)ethene